Children

This first-in-human study of golodirsen showed its long-term safety and biologic activity in patients with Duchenne Muscular Dystrophy (DMD). The approved exon-skipping therapy is designed to enable the production of functional dystrophin proteins, as described in the peer-reviewed journal Nucleic Acid Therapeutics. Golodirsen was tested in ambulatory patients with exon 53 skip amenable DMD. They

Many countries have implemented various nonpharmaceutical interventions (NPIs) such as social distancing mandates and lockdowns in response to the coronavirus disease 19 (COVID-19) pandemic. Although these measures reduced stress on the healthcare system in the absence of vaccines, they were associated with major socioeconomic costs. This led to a revival of the debate on whether

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive. Journal in Which the Study was Published: Blood Cancer Discovery, a journal of the American

“Put down your phone” is a common parental phrase, the modern-day equivalent of “turn off the TV.” That’s because parents have long thought that staring at a screen for too long will have a detrimental effect. However, parental concerns about media use appeared to take a backseat in 2020, when COVID-19 forced parents to make

As the COVID-19 pandemic nears the two-year mark, Northwestern Medicine scientists continue to tackle every facet of the disease, from investigating coronavirus vaccines’ potential for providing immunity against similar coronaviruses to developing novel rapid antigen-based tests and examining disparities in COVID-19 case and mortality rates in Chicago. Coronavirus vaccines may provide cross-protective immunity Northwestern Medicine

During the first 9 months of the COVID-19 pandemic, researchers did not find a significant difference in the number of new cancer diagnoses in Canadian children compared with before the pandemic, according to a study published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.210659. “Our findings suggest that among children in Canada, cancer diagnosis was not

Saliva samples are easy to obtain and useful for measuring antibodies to SARS-CoV-2 in children, which could facilitate epidemiological surveillance in school settings. The study, a collaboration between the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation, and the Hospital Sant Joan de Déu (HSJD), followed over 1,500 children who

A team of UK-based scientists has recently evaluated the effectiveness of coronavirus disease 2019 (COVID-19) vaccines in preventing household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in England. Their findings indicate that the vaccines effectively reduce transmission of SARS-CoV-2 alpha and delta variants from breakthrough infections in the household setting, despite having reduced

We all know that if we don’t get enough sleep or don’t sleep well, we won’t be on top of our game the next day. And we know that many teens and preteens get too little or poor-quality sleep. Now, a large, first-of-its kind study from Boston Children’s Hospital spells out in detail how inadequate

Multisystem inflammatory syndrome (MIS) is a new systemic inflammatory acute onset disease that mainly affects children (MIS-C) and, at a lesser frequency, adults. The disease usually occurs in children 3-6 weeks after acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Study: Autoantibody Release in Children after Corona Virus mRNA Vaccination: A Risk Factor of

Researchers at Yale University analyzing specialized MRI exams found significant changes in the microstructure of the brain’s white matter in adolescents and young adults with autism spectrum disorder (ASD) compared to a control group, according to research being presented next week at the annual meeting of the Radiological Society of North America (RSNA). The changes

Quarraisha Abdool Karim has spent the past three decades studying HIV and AIDS. She has become one of the world’s leading epidemiologists and made major contributions to the global understanding of how HIV affects young women. As associate scientific director of the Centre for the AIDS Programme of Research in South Africa (CAPRISA), Abdool Karim

The perception of gender in children’s voices is of special interest to researchers, because voices of young boys and girls are very similar before the age of puberty. Adult male and female voices are often quite different acoustically, making gender identification fairly easy. Gender perception is much more complicated in children because gender differences in

Earlier this year, the U.S. Food & Drug Administration (FDA) approved COVID-19 vaccines for 12 to 15 years and people over the age of 16. While adolescents have been less at risk for severe COVID-19 illness, new variants such as Delta have caused a surge in infections in this age group. New research from the

Cynthia Rogers, MD, visits a baby in the Newborn Intensive Care Unit at St. Louis Children’s Hospital. Rogers is helping lead a national study aimed at understanding how prenatal factors and early life experiences influence brain development and behavior in infants and young children. Researchers at Washington University School of Medicine in St. Louis are

A new study summarized in a research letter published in JAMA Pediatrics reveals that a number of factors, including negative impacts from the pandemic during pregnancy, health care experiences, and reports of discrimination, made it less likely that infants received their recommended vaccinations in the first months of their lives. Led by Heidi Preis, MSW,

Washington University in St. Louis is joining a major international effort to advance data science, catalyze innovation and spur health discoveries across Africa. Researchers at the School of Medicine are receiving one of 19 grant awards that will support data science research and training activities in Africa. The researchers will focus their efforts on developing

One of the primary tools that oncologists use to stage cancers is the PET (positron emission tomography) scan, an imaging test that uses a small amount of radioactive sugar to detect metabolically active areas within the body. CU Cancer Center member Sarah Milgrom, MD, recently conducted research to study if PET scans can help to

A recent study found that the drug tranexamic acid has minimal impact in controlling blood loss in severely injured trauma patients at the standard doses given, according to researchers at Washington University School of Medicine in St. Louis. The drug, also called TXA, is routinely given at many hospitals across the U.S. to critically injured

In the sixth-most populated state of India – Tamil Nadu, three rounds of a district-level serological study were conducted through two COVID waves. Round 1 of the study was conducted from 19th Oct to 30th Nov 2020, round 2 from 7th to 30th Apr 2021, and round 3 from 28th June to 7th July 2021.

Weill Cornell Medicine has received a $1.27 million grant from the United States Department of Defense (DoD) to develop treatment for a rare but devastating eye condition largely affecting military personnel who suffer traumatic eye injuries in combat. Under the three-year grant, investigators will test the safety and effectiveness of two newly developed antibodies to

A study currently available on the medRxiv* preprint server has demonstrated that the incidence and mortality rates of coronavirus disease 2019 (COVID-19) in the US can be significantly reduced at the population level by increasing vaccinate rates from 40% to 80%. An increased vaccination rate has a protective effect on the entire population, not just

Researchers from the University of Eastern Finland, the University of Exeter, and the University of Bristol carried out the study using data from one of the world’s most extensive ongoing prospective birth cohort studies – the Avon Longitudinal Study of Parents and Children (ALSPAC). Atherosclerotic traits referred to as arterial stiffness seem to independently cause

Melissa Blatzer was determined to get her three children caught up on their routine immunizations on a recent Saturday morning at a walk-in clinic in this Denver suburb. It had been about a year since the kids’ last shots, a delay Blatzer chalked up to the pandemic. Two-year-old Lincoln Blatzer, in his fleece dinosaur pajamas,

The Marker family opened their door on a recent evening to a woman dressed in purple, with a military attitude to cleanliness. Linda Holmes, who has worked as a technician with LiceDoctors for five years, came straight from her day job at a hospital after she got the call from a dispatcher that the Marker

Researchers have compiled the most comprehensive road map of the protein composition of human lungs, providing a clearer picture of the healthy development of this essential organ that made terrestrial life possible. The study, led by scientists at the Department of Energy’s Pacific Northwest National Laboratory, describes how thousands of molecules are modulated in a

The coronavirus disease 2019 (COVID-19) outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a sharp rise in deaths and the number of infections worldwide. The pandemic has resulted in the deaths of more than 5.1 million people from more than 254 million infections as of November 18, 2021. Therefore,

Valsartan, an angiotensin II receptor blocker drug, delayed disease progression and improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy, according to results from a recent clinical trial published in Nature Medicine. This is the first time we have identified a treatment that may actually impact the underlying disease process, as opposed to