Clinical Trials & Research

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has significantly impacted the healthcare system and the global economy. To date, COVID-19 has claimed more than 5.21 million lives worldwide. Study: Main protease mutants of SARS-CoV-2 variants remain susceptible to PF-07321332. Image Credit: Kateryna Kon/Shutterstock Background In response
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In a recent preprint study researchers from the UK predicted the infection rate by far-field airborne transmission (that occurs at distances of greater than two meters) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indoors – showing the probability of transmission increase with occupancy. The researchers observed that far-field transmission is likely to be a
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Much of the current discussion on reducing the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has wrongly focused on the effectiveness of individual interventions, especially vaccination. As new virus variants emerge, with increased transmissibility and immune evasion properties, it seems indubitable that various protective measures must be combined to achieve a synergistic
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The appearance of objects can often change. For example, in dim evenings or fog, the contrast of the objects decreases, making it difficult to distinguish them. However, after repeatedly encountering specific objects, the brain can identify them even if they become indistinct. The exact mechanism contributing to the perception of low-contrast familiar objects remains unknown.
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The infection prevention and control (IPC) measures initially implemented to limit transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during 2020 and 2021 successfully reduced the incidence and transmission of coronavirus disease 2019 (COVID-19) and other respiratory tract viruses. Study: A comparison of health care use after severe COVID-19, respiratory syncytial virus, and influenza
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Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it has undergone several mutations giving rise to different variants of the virus. The current and most notorious variant among them is the Delta variant. It is more contagious and infectious compared to the previous variants of SARS-CoV-2. Therefore, the Delta variant has been
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Coronavirus disease 2019 (COVID-19) vaccines effectively prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related illness and death.  Because COVID-19 vaccines are not 100% effective in preventing illness, certain infections among those who have been vaccinated are expected. The involvement of vaccinated people in the transmission will be a major predictor of the pandemic’s future trajectory
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Contact tracing has been a core component of the public health response to the coronavirus 2019 (COVID-19) pandemic. Its main objective is to interrupt transmission chains by identifying people who had contact with a case to promptly quarantine people at risk of infection, thereby reducing further transmission. This is to effectively minimize the workload for public
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Scientists at Scripps Research, Florida have determined the near-atomic-scale structure of an unusual brain-cell receptor called GPR158, which has been linked to depression and anxiety. The structural study reveals both the receptor and its regulating complex, advancing understanding of basic cell receptor biology. It also enables work on potential therapeutics designed to block GPR158 as
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Today, CDC Director Rochelle P. Walensky, M.D., M.P.H., endorsed the CDC Advisory Committee on Immunization Practices’ (ACIP) expanded recommendations for booster shots to include all adults ages 18 years and older who received a Pfizer-BioNTech or Moderna vaccine at least six months after their second dose. The Food and Drug Administration’s (FDA) authorization and CDC’s
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The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals and has claimed more than 5 million lives worldwide. According to the World Health Organization, globally, around 290000–650000 people die from influenza every year. Previous studies have indicated that individuals above 65 years and children
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Duy Hoa Tran, a retired Vietnamese schoolteacher, arrived in Los Angeles in February 2020 to visit his daughter and 2-month-old grandson. Two weeks later, the door closed behind him. To prevent the spread of covid-19, Vietnam shut its borders. No commercial flights would be allowed into the country for the next 18 months. Tran’s daughter,
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A study involving UT Southwestern neurology researchers found lower-quality outcomes for Hispanic ischemic stroke patients who receive endovascular thrombectomies than for comparable white and Black patients. Outcomes were similar between Black and white ischemic stroke patients who receive endovascular thrombectomies, the researchers determined. Ischemic strokes block or narrow an artery leading to the brain. The
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The spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic and caused health, social and economic crises. To tackle this, vaccination and non-pharmaceutical interventions (NPIs) were considered essential to contain the virus and reduce casualties, which have crossed five million worldwide as of now. Study: Myocarditis After
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A team led by scientists at Baylor College of Medicine uncovered new evidence supporting a cancer-promoting role for enzyme MAPK6. The study, published in the journal Science Advances, shows that MAPK6 furthers cancer growth by activating the AKT pathway, a known cancer-promoting cellular mechanism. The findings suggest that therapies directed at interfering with MAPK6 activity
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Immune checkpoint inhibitors are a type of cancer treatment that help the immune system’s T cells recognize and attack tumors. But these immunotherapy drugs aren’t effective against all cancers. In a study published today in Science Advances, University of Pittsburgh and UPMC researchers reveal how certain cells drive immunotherapy resistance in a mouse model of
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Nov 11 2021 The Pancreatic Cancer Collective, an initiative of the Lustgarten Foundation and Stand Up To Cancer® (SU2C), announced today the launch of a new public service announcement (PSA) campaign. In collaboration with SU2C Ambassadors – actor and comedian Marlon Wayans, and actress and Emmy® Award-winning comedian Tiffany Haddish – the PSA aims to
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CN Bio, a leading Organ-on-a-chip Company (OOC) that designs and manufactures single- and multi-organ microphysiological systems (MPS), today announced a research collaboration with the Infection Innovation Consortium (iiCON), a global collaborative infectious disease R&D programme, to validate the next generation of COVID-19 research tools. iiCON’s £174 million programme brings together industry, academia, and clinicians to
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When state senators in South Carolina held two hearings in September about covid-19 treatments, they got an earful on the benefits of ivermectin — which many of the lawmakers echoed, sharing experiences of their own loved ones. The demands for access to the drug were loud and insistent, despite federal regulators’ recent warning against using
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Scientists at the Francis Crick Institute have found how the immune system triggers an ’emergency’ dendritic cell response during infection, with dendritic cells at the site of infection being reinforced by new cells which travel from the bone marrow. Dendritic cells have an important role in the immune system, detecting infectious bacteria, fungi or viruses
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Today bit.bio announces the first close of their Series B financing of $103 million. New and existing institutional and strategic investors in the Series B round, thus far, include Arch Ventures, Charles River Laboratories, Foresite Capital, National Resilience, Inc. (Resilience), Metaplanet, Puhua Capital and Tencent. The funding will accelerate the clinical development of the company’s
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Younger patients with specific genetic subtypes of non-GCB DLBCL, called MCD and N1, had an exceptional response to the treatment combination. New evidence suggests that adding the targeted therapy ibrutinib (Imbruvica) to a standard chemotherapy regimen can improve how long some younger people with a specific form of diffuse large B-cell lymphoma (DLBCL) live. The
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