Clinical Trials & Research

In a new study led by Yale Cancer Center, researchers show the nucleoside transporter ENT2 may offer an unexpected path to circumventing the blood-brain barrier (BBB) and enabling targeted treatment of brain tumors with a cell-penetrating anti-DNA autoantibody. The study was published today online in the Journal of Clinical Investigation Insight. “These findings are very
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The vaccination program has commenced in many countries worldwide, which is marked as a significant milestone in curbing the spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the coronavirus disease 2019 (COVID-19) pandemic. These vaccines, which have received emergency authorization from different regulatory bodies around the world, such as the
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Positron emission tomography (PET) using a 68Ga-labeled fibroblast activation protein inhibitor (FAPI) can noninvasively identify and monitor pulmonary fibrosis, according to research presented at the Society of Nuclear Medicine and Molecular Imaging 2021 Annual Meeting. By binding to activated fibroblasts present in affected lungs, FAPI-PET allows for direct imaging of the disease process. Idiopathic pulmonary
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The term “doomscrolling” describes the act of endlessly scrolling through bad news on social media and reading every worrisome tidbit that pops up, a habit that unfortunately seems to have become common during the COVID-19 pandemic. The biology of our brains may play a role in that. Researchers at Washington University School of Medicine in
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In British Columbia (BC), Canada, vaccination against coronavirus disease 2019 (COVID-19) began with the Pfizer/Moderna mRNA (messenger ribonucleic acid) vaccines began with nursing home residents and frontline healthcare workers. New research by scientists in Canada suggests that these are known to have a high protective efficacy of 92-93% after a single dose, but this data
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A team of scientists in Estonia has recently evaluated the therapeutic/prophylactic efficacy of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polyclonal antibodies derived from the colostrum of immunized cows. The antibodies exhibit high efficiency in inhibiting the interaction between SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 (ACE2). Furthermore, the scientists have prepared a nasal
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The continuing spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) globally has not only taken a great toll on human health but threatens the economic stability of the human race. SARS-CoV-2, which is the virus responsible for the coronavirus disease 2019 (COVID-19), is unpredictable in its effects, as it has the potential to
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Researchers in the UK have demonstrated the potential of modulating the expression of angiotensin-converting enzyme 2 (ACE2) as a novel host-directed therapeutic approach to protecting against coronavirus disease 2019 (COVID-19). The human ACE2 receptor is the main host structure that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to as the initial stage of the
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Today, the U.S. Food and Drug Administration approved Aduhelm (aducanumab) for the treatment of Alzheimer’s, a debilitating disease affecting 6.2 million Americans. Aduhelm was approved using the accelerated approval pathway, which can be used for a drug for a serious or life-threatening illness that provides a meaningful therapeutic advantage over existing treatments. Accelerated approval can
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Cancer researchers say they have established a new, life-extending treatment option for men with prostate cancer that has spread and become resistant to hormone therapy. The injected treatment combines a targeting compound with a radioactive isotope to irradiate and kill cancer cells. An international clinical trial sponsored by Endocyte, Inc., a Novartis company tested the
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Once a virus infects a cell, neighboring cells are likely to become infected by interactions that are dependent on the cell and the virus in question. For example, cell-to-cell spread is facilitated in HIV by viral synapses, which also allow for escape from neutralizing antibodies. Low-level drug inhibitors are able to suppress infection if applied
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The first person to receive a coronavirus disease 2019 (COVID-19) vaccine outside a clinical trial did so within 250 days of the first case of COVID-19 being reported to the World Health Organization (WHO) in late 2019. Mass vaccination efforts are now a key strategy for controlling the pandemic. Several vaccines have been approved, including
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Jun 1 2021 Investigators from Trinity College Dublin, the Irish Mycobacteria Reference Laboratory, St James’s Hospital, and the Department of Public Health HSE East believe tuberculosis (TB) care in Irish Prisons should be supported, considering the findings of their study which is published today (Tuesday, 1st June, 2021) in the International Journal of Tuberculosis and
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By including multi-ethnic participants, a largescale genetic study has identified more regions of the genome linked to type 2 diabetes-related traits than if the research had been conducted in Europeans alone. The international MAGIC collaboration, made up of more than 400 global academics, conducted a genome-wide association meta-analysis led by the University of Exeter. Now
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To mark World Vape Day, BAT has today published a comprehensive review of the scientific evidence for vaping products (e-cigarettes), their potential health effects and their role in Tobacco Harm Reduction. This review shows that, over the past decade, the number of people who incorrectly believe vaping is as harmful or more harmful than smoking
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Even as over a score of vaccines against the coronavirus disease 2019 (COVID-19) pandemic have been rolled out following their emergence use authorization, others continue to be researched to fill the global need for effective deployment the world over. A new study, published in Nano Letters, describes an effective new vaccine candidate based on a
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WHAT: The immune system’s attempt to eliminate Salmonella bacteria from the gastrointestinal (GI) tract instead facilitates colonization of the intestinal tract and fecal shedding, according to National Institutes of Health scientists. The study, published in Cell Host & Microbe, was conducted by National Institute of Allergy and Infectious Diseases (NIAID) scientists at Rocky Mountain Laboratories
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The World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) pandemic in March 2020, owing to the rapid worldwide spread of its causative virus: severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This is a positive-sense RNA virus that causes mild to critical infection. Several COVID-19 vaccines have received emergency authorization by national regulatory authorities in
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People who come in contact with coronavirus disease 2019 (COVID-19) patients are high-risk individuals for becoming infected with its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Viral transmission in hospitals is a particular area of concern, as the close interaction between the healthcare personnel and the patients helps the transmission of the virus
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COVID-19 vaccines are the most effective way to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. For people who are already infected, new research suggests the small molecule stimulator of interferon genes (STING) agonist-1, diABZI, may be effective in controlling SARS-CoV-2 infection — including those caused by variants. Led by Sara Cherry from the
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Micropollutants such as steroid hormones contaminate drinking water worldwide and pose a significant threat to human health and the environment even in smallest quantities. Until now, easily scalable water treatment technologies that remove them efficiently and sustainably have been lacking. Scientists at the Karlsruhe Institute of Technology (KIT) developed a new chemical process for removing
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The spike (S) proteins on the surface of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial in determining the infectivity and antigenicity of the virus. The spike protein has already undergone several mutations, and these mutations have influenced immune system evasion and boosted viral transmission. This has led to increased morbidity and mortality, and
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